Pulmonary infection by Yersinia pestis rapidly establishes a permissive environment for microbial proliferation
نویسندگان
چکیده
منابع مشابه
Pulmonary infection by Yersinia pestis rapidly establishes a permissive environment for microbial proliferation.
Disease progression of primary pneumonic plague is biphasic, consisting of a preinflammatory and a proinflammatory phase. During the long preinflammatory phase, bacteria replicate to high levels, seemingly uninhibited by normal pulmonary defenses. In a coinfection model of pneumonic plague, it appears that Yersinia pestis quickly creates a localized, dominant anti-inflammatory state that allows...
متن کاملAsymptomatic Yersinia pestis Infection, China
Salmonella infection may be increased by alterations in the gastrointestinal tract, including decreased gastric acidity and chronic gastrointestinal disease. Leukocytosis was noted in 25% of patients. In fact, two thirds of the patients had a normal leukocyte count with immature leukocytes, which may be attributable to their relatively impaired cell-mediated immunity. The predominant organism i...
متن کاملYersinia pestis and Yersinia pseudotuberculosis infection: a regulatory RNA perspective
Yersinia pestis, responsible for causing fulminant plague, has evolved clonally from the enteric pathogen, Y. pseudotuberculosis, which in contrast, causes a relatively benign enteric illness. An ~97% nucleotide identity over 75% of their shared protein coding genes is maintained between these two pathogens, leaving much conjecture regarding the molecular determinants responsible for producing ...
متن کاملS1P-Dependent trafficking of intracellular yersinia pestis through lymph nodes establishes Buboes and systemic infection.
Pathologically swollen lymph nodes (LNs), or buboes, characterize Yersinia pestis infection, yet how they form and function is unknown. We report that colonization of the draining LN (dLN) occurred due to trafficking of infected dendritic cells and monocytes in temporally distinct waves in response to redundant chemotactic signals, including through CCR7, CCR2, and sphingosine-1-phospate (S1P) ...
متن کاملYersinia pestis: New Evidence for an Old Infection
The successful reconstruction of an ancient bacterial genome from archaeological material presents an important methodological advancement for infectious disease research. The reliability of evolutionary histories inferred by the incorporation of ancient data, however, are highly contingent upon the level of genetic diversity represented in modern genomic sequences that are publicly accessible,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2012
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1112729109